Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia

Osteonecrosis is a severe glucocorticoid-induced complication of acute lymphoblastic leukemia treatment. We prospectively screened children (n = 364) with magnetic resonance imaging of hips and knees, regardless of symptoms; the cumulative incidence of any (grade 1-4) versus symptomatic (grade 2-4)...

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Autors principals: Kawedia, Jitesh D., Kaste, Sue C., Pei, Deqing, Panetta, John C., Cai, Xiangjun, Cheng, Cheng, Neale, Geoffrey, Howard, Scott C., Evans, William E., Pui, Ching-Hon, Relling, Mary V.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Clinical Trials and Observations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062406/
https://ncbi.nlm.nih.gov/pubmed/21148812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-311969
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