Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia

Glucocorticoids are important therapy for acute lymphoblastic leukemia (ALL) and their major adverse effect is osteonecrosis. Our goal was to identify genetic and nongenetic risk factors for osteonecrosis. We performed a genome-wide association study of single nucleotide polymorphisms (SNPs) in a di...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Karol, Seth E., Yang, Wenjian, Van Driest, Sara L., Chang, Tamara Y., Kaste, Sue, Bowton, Erica, Basford, Melissa, Bastarache, Lisa, Roden, Dan M., Denny, Joshua C., Larsen, Eric, Winick, Naomi, Carroll, William L., Cheng, Cheng, Pei, Deqing, Fernandez, Christian A., Liu, Chengcheng, Smith, Colton, Loh, Mignon L., Raetz, Elizabeth A., Hunger, Stephen P., Scheet, Paul, Jeha, Sima, Pui, Ching-Hon, Evans, William E., Devidas, Meenakshi, Mattano, Leonard A., Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600016/
https://ncbi.nlm.nih.gov/pubmed/26265699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-643601
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