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CYP3A-Mediated Generation of Aldehyde and Hydrazine in Atazanavir Metabolism
Atazanavir (ATV) is an antiretroviral drug of the protease inhibitor class. Multiple adverse effects of ATV have been reported in clinical practice, such as jaundice, nausea, abdominal pain, and headache. The exact mechanisms of ATV-related adverse effects are unknown. It is generally accepted that...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3061559/ https://ncbi.nlm.nih.gov/pubmed/21148252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.036327 |
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