Metabolism-Mediated Drug Interactions Associated with Ritonavir-Boosted Tipranavir in Mice

Tipranavir (TPV) is the first nonpeptidic protease inhibitor used for the treatment of drug-resistant HIV infection. Clinically, TPV is coadministered with ritonavir (RTV) to boost blood concentrations and increase therapeutic efficacy. The mechanism of metabolism-mediated drug interactions associat...

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Bibliographic Details
Main Authors: Li, Feng, Wang, Laiyou, Guo, Grace L., Ma, Xiaochao
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872945/
https://ncbi.nlm.nih.gov/pubmed/20103582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.030817
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