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Drug-Drug Interaction Study of Ketoconazole and Ritonavir-Boosted Saquinavir
Saquinavir, a potent human immunodeficiency virus protease inhibitor, is extensively metabolized by CYP3A4. Saquinavir is coadministered with ritonavir, a strong CYP3A4 inhibitor, to boost its exposure. Ketoconazole is a potent CYP3A inhibitor. The objectives of this study were to investigate the ef...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology (ASM)
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630604/ https://ncbi.nlm.nih.gov/pubmed/19015329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00769-08 |
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