Drug-Drug Interaction Study of Ketoconazole and Ritonavir-Boosted Saquinavir

Saquinavir, a potent human immunodeficiency virus protease inhibitor, is extensively metabolized by CYP3A4. Saquinavir is coadministered with ritonavir, a strong CYP3A4 inhibitor, to boost its exposure. Ketoconazole is a potent CYP3A inhibitor. The objectives of this study were to investigate the ef...

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Detaylı Bibliyografya
Asıl Yazarlar: Kaeser, Benoite, Zandt, Hagen, Bour, Fabrice, Zwanziger, Elke, Schmitt, Christophe, Zhang, Xiaoping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2009
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630604/
https://ncbi.nlm.nih.gov/pubmed/19015329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00769-08
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