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CPY3A4-Mediated α-Hydroxyaldehyde Formation in Saquinavir Metabolism
Saquinavir (SQV) is a protease inhibitor widely used for the treatment of human immunodeficiency virus (HIV) infection. We profiled SQV metabolism in mice using a metabolomic approach. Thirty SQV metabolites were identified in mouse feces and urine, of which 20 are novel. Most metabolites observed i...
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| Asıl Yazarlar: | , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3912542/ https://ncbi.nlm.nih.gov/pubmed/24212380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.054874 |
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