Altering dimerization specificity by changes in surface electrostatics
Arc repressor forms a homodimer in which the subunits intertwine to create a single globular domain. To obtain Arc sequences that fold preferentially as heterodimers, variants with surface patches of excess positive or negative charge were designed. Several but not all oppositely charged sequence pa...
Gardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2001
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30615/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051624498 |
| Tags: |
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|