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Altering dimerization specificity by changes in surface electrostatics
Arc repressor forms a homodimer in which the subunits intertwine to create a single globular domain. To obtain Arc sequences that fold preferentially as heterodimers, variants with surface patches of excess positive or negative charge were designed. Several but not all oppositely charged sequence pa...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC30615/ https://ncbi.nlm.nih.gov/pubmed/11248040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051624498 |
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