Altering dimerization specificity by changes in surface electrostatics
Arc repressor forms a homodimer in which the subunits intertwine to create a single globular domain. To obtain Arc sequences that fold preferentially as heterodimers, variants with surface patches of excess positive or negative charge were designed. Several but not all oppositely charged sequence pa...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30615/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051624498 |
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