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Site-Directed Mutations near Transmembrane Domain 1 Alter Conformation and Function of Norepinephrine and Dopamine Transporters

The human dopamine and norepinephrine transporters (hDAT and hNET, respectively) control neurotransmitter levels within the synaptic cleft and are the site of action for amphetamine (AMPH) and cocaine. We investigated the role of a threonine residue within the highly conserved and putative phosphory...

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Bibliografiske detaljer
Main Authors: Guptaroy, Bipasha, Fraser, Rheaclare, Desai, Aalisha, Zhang, Minjia, Gnegy, Margaret E.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061360/
https://ncbi.nlm.nih.gov/pubmed/21149640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.069039
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