A Juxtamembrane Mutation in the N Terminus of the Dopamine Transporter Induces Preference for an Inward-Facing Conformation

The human dopamine transporter (hDAT) regulates synaptic dopamine (DA) levels and is the site of action of abused and therapeutic drugs. Here we study the effect of a threonine residue (Thr62 in hDAT) that is highly conserved within a canonical phosphorylation site (RETW) in the juxtamembrane N-term...

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Detalhes bibliográficos
Main Authors: Guptaroy, Bipasha, Zhang, Minjia, Bowton, Erica, Binda, Francesca, Shi, Lei, Weinstein, Harel, Galli, Aurelio, Javitch, Jonathan A., Neubig, Richard R., Gnegy, Margaret E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684905/
https://ncbi.nlm.nih.gov/pubmed/19098122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.048744
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