Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in cellular defence against oxidative stress by inducing the expression of multiple anti-oxidant genes. However, where high levels of oxidative stress are observed, such as chronic obstructive pulmonary disease (COPD), Nrf2 acti...

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Hlavní autoři: Mercado, Nicolas, Thimmulappa, Rajesh, Thomas, Catherine M.R., Fenwick, Peter S., Chana, Kirandeep K., Donnelly, Louise E., Biswal, Shyam, Ito, Kazuhiro, Barnes, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Academic Press 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061319/
https://ncbi.nlm.nih.gov/pubmed/21320471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.02.035
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