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Potential therapeutic applications of antisense morpholino oligonucleotides in modulation of splicing in primary immunodeficiency diseases
Highly complementary antisense morpholino oligonucleotides (AMOs) can bind to pre-mRNA and modulate splicing site selection. This offers a powerful tool to regulate splicing process, such as correcting subtypes of splicing mutations and nonsense mutations and reprogramming alternative splicing proce...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3061259/ https://ncbi.nlm.nih.gov/pubmed/21147113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2010.12.001 |
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