Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

The reactivation of telomerase activity in most cancer cells supports the concept that telomerase is a relevant target in oncology, and telomerase inhibitors have been proposed as new potential anticancer agents. The telomeric G-rich single-stranded DNA can adopt in vitro an intramolecular quadruple...

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Main Authors: Mergny, Jean-Louis, Lacroix, Laurent, Teulade-Fichou, Marie-Paule, Hounsou, Candide, Guittat, Lionel, Hoarau, Magali, Arimondo, Paola B., Vigneron, Jean-Pierre, Lehn, Jean-Marie, Riou, Jean-François, Garestier, Thérèse, Hélène, Claude
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC30607/
https://ncbi.nlm.nih.gov/pubmed/11248032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051620698
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