A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells

Telomeres protect chromosome ends from being recognized as double-stranded breaks. Telomeric function is ensured by the shelterin complex in which TRF2 protein is an essential player. The G-rich strand of telomere DNA can fold into G-quadruplex (G4) structure. Small molecules stabilizing G4 structur...

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Main Authors: Gomez, Dennis, Guédin, Aurore, Mergny, Jean-Louis, Salles, Bernard, Riou, Jean-François, Teulade-Fichou, Marie-Paule, Calsou, Patrick
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
Assuntos:
RNA
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978344/
https://ncbi.nlm.nih.gov/pubmed/20571083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq563
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