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A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells
Telomeres protect chromosome ends from being recognized as double-stranded breaks. Telomeric function is ensured by the shelterin complex in which TRF2 protein is an essential player. The G-rich strand of telomere DNA can fold into G-quadruplex (G4) structure. Small molecules stabilizing G4 structur...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978344/ https://ncbi.nlm.nih.gov/pubmed/20571083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq563 |
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