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Transcriptional activators enhance polyadenylation of mRNA precursors

Polyadenylation of mRNA precursors is frequently coupled to transcription by RNA polymerase II. Although this coupling is known to involve interactions with the C-terminal domain of the RNA polymerase II largest subunit, the possible role of other factors is not known. Here we show that a prototypic...

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Autors principals: Nagaike, Takashi, Logan, Charlotte, Hotta, Ikuko, Rozenblatt-Rosen, Orit, Meyerson, Matthew, Manley, James L.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060669/
https://ncbi.nlm.nih.gov/pubmed/21329879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.01.022
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