Regional genomic regulation of cardiac sodium–calcium exchanger by oestrogen

Female rabbit hearts are more susceptible to torsade de pointes (TdP) in acquired long QT type 2 than males, in-part due to higher L-type Ca(2+) current (I(Ca,L)) at the base of the heart. In principle, higher Ca(2+) influx via I(Ca,L) should be balanced by higher efflux, perhaps mediated by paralle...

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Bibliografiske detaljer
Main Authors: Chen, Guojun, Yang, Xiaoyan, Alber, Sean, Shusterman, Vladimir, Salama, Guy
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2011
Fag:
Molecular and Cellular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060587/
https://ncbi.nlm.nih.gov/pubmed/21224239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.203398
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