Polyubiquitin Linkage Profiles in Three Models of Proteolytic Stress Suggest the Etiology of Alzheimer Disease

Polyubiquitin chains on substrates are assembled through any of seven lysine residues or the N terminus of ubiquitin (Ub), generating diverse linkages in the chain structure. PolyUb linkages regulate the fate of modified substrates, but their abundance and function in mammalian cells are not well st...

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Détails bibliographiques
Auteurs principaux: Dammer, Eric B., Na, Chan Hyun, Xu, Ping, Seyfried, Nicholas T., Duong, Duc M., Cheng, Dongmei, Gearing, Marla, Rees, Howard, Lah, James J., Levey, Allan I., Rush, John, Peng, Junmin
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Protein Synthesis and Degradation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060499/
https://ncbi.nlm.nih.gov/pubmed/21278249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149633
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