Quantitative Phosphoproteomics of Alzheimer's Disease Reveals Crosstalk between Kinases and Small Heat Shock Proteins

Abnormal phosphorylation contributes to the formation of neurofibrillary tangles in Alzheimer Disease (AD), but may play other signaling roles during AD pathogenesis. In this study, we employed immobilized metal affinity chromatography (IMAC) followed by liquid chromatography-tandem mass spectrometr...

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Udgivet i:Proteomics
Main Authors: Dammer, Eric B., Lee, Andrew K., Duong, Duc M., Gearing, Marla, Lah, James J., Levey, Allan I., Seyfried, Nicholas T
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404162/
https://ncbi.nlm.nih.gov/pubmed/25332170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201400189
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