Quantitative Phosphoproteomics of Alzheimer's Disease Reveals Crosstalk between Kinases and Small Heat Shock Proteins

Abnormal phosphorylation contributes to the formation of neurofibrillary tangles in Alzheimer Disease (AD), but may play other signaling roles during AD pathogenesis. In this study, we employed immobilized metal affinity chromatography (IMAC) followed by liquid chromatography-tandem mass spectrometr...

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Pubblicato in:Proteomics
Autori principali: Dammer, Eric B., Lee, Andrew K., Duong, Duc M., Gearing, Marla, Lah, James J., Levey, Allan I., Seyfried, Nicholas T
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404162/
https://ncbi.nlm.nih.gov/pubmed/25332170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201400189
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