Multiplex SILAC Analysis of a Cellular TDP-43 Proteinopathy Model Reveals Protein Inclusions Associated with SUMOylation and Diverse Polyubiquitin Chains

Transactive response (TAR) DNA-binding protein 43 (TDP-43) is a major protein component within ubiquitin-positive inclusions of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Although TDP-43 is a nuclear DNA/RNA-binding protein, in pathological conditions, TDP-43 has been repor...

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Detalhes bibliográficos
Main Authors: Seyfried, Nicholas T., Gozal, Yair M., Dammer, Eric B., Xia, Qiangwei, Duong, Duc M., Cheng, Dongmei, Lah, James J., Levey, Allan I., Peng, Junmin
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860236/
https://ncbi.nlm.nih.gov/pubmed/20047951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M800390-MCP200
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