Gcn1 and Actin Binding to Yih1: IMPLICATIONS FOR ACTIVATION OF THE eIF2 KINASE GCN2

Yeast Yih1 protein and its mammalian ortholog IMPACT, abundant in neurons, are inhibitors of Gcn2, a kinase involved in amino acid homeostasis, stress response, and memory formation. Like Gcn2, Yih1/IMPACT harbors an N-terminal RWD domain that mediates binding to the Gcn2 activator Gcn1. Yih1 compet...

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Detalhes bibliográficos
Main Authors: Sattlegger, Evelyn, Barbosa, João A. R. G., Moraes, Maria Carolina S., Martins, Rafael M., Hinnebusch, Alan G., Castilho, Beatriz A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060488/
https://ncbi.nlm.nih.gov/pubmed/21239490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.171587
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