Cortisol Synthesis in Epidermis Is Induced by IL-1 and Tissue Injury

Glucocorticoids (GCs) are known inhibitors of wound healing. In this study we report the novel finding that both keratinocytes in vitro and epidermis in vivo synthesize cortisol and how this synthesis regulates wound healing. We show that epidermis expresses enzymes essential for cortisol synthesis,...

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Bibliographische Detailangaben
Hauptverfasser: Vukelic, Sasa, Stojadinovic, Olivera, Pastar, Irena, Rabach, Morgan, Krzyzanowska, Agata, Lebrun, Elizabeth, Davis, Stephen C., Resnik, Sydney, Brem, Harold, Tomic-Canic, Marjana
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060481/
https://ncbi.nlm.nih.gov/pubmed/21239489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.188268
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