Cortisol Synthesis in Epidermis Is Induced by IL-1 and Tissue Injury

Glucocorticoids (GCs) are known inhibitors of wound healing. In this study we report the novel finding that both keratinocytes in vitro and epidermis in vivo synthesize cortisol and how this synthesis regulates wound healing. We show that epidermis expresses enzymes essential for cortisol synthesis,...

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Detalhes bibliográficos
Main Authors: Vukelic, Sasa, Stojadinovic, Olivera, Pastar, Irena, Rabach, Morgan, Krzyzanowska, Agata, Lebrun, Elizabeth, Davis, Stephen C., Resnik, Sydney, Brem, Harold, Tomic-Canic, Marjana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060481/
https://ncbi.nlm.nih.gov/pubmed/21239489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.188268
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