Deregulation of epidermal stem cell niche contributes to pathogenesis of non-healing venous ulcers

The epidermis is maintained by epidermal stem cells (ESC) that reside in distinct niches and contribute to homeostasis and wound closure. Keratinocytes at the non-healing edges of venous ulcers (VUs) are healing-incompetent, hyper-proliferative and non-migratory suggesting deregulation of ESCs. To d...

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Bibliographic Details
Published in:Wound Repair Regen
Main Authors: Stojadinovic, Olivera, Pastar, Irena, Nusbaum, Aron G., Vukelic, Sasa, Krzyzanowska, Agata, Tomic-Canic, Marjana
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329920/
https://ncbi.nlm.nih.gov/pubmed/24635172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/wrr.12142
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