Synthesis and Characterization of Pseudocantharidins, Novel Phosphatase Modulators That Promote the Inclusion of Exon 7 into the SMN (Survival of Motoneuron) pre-mRNA

Alternative pre-mRNA splicing is a central element of eukaryotic gene expression. Its deregulation can lead to disease, and methods to change splice site selection are developed as potential therapies. Spinal muscular atrophy is caused by the loss of the SMN1 (survival of motoneuron 1) gene. A thera...

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Detalhes bibliográficos
Main Authors: Zhang, Zhaiyi, Kelemen, Olga, van Santen, Maria A., Yelton, Sharon M., Wendlandt, Alison E., Sviripa, Vitaliy M., Bollen, Mathieu, Beullens, Monique, Urlaub, Henning, Lührmann, Reinhard, Watt, David S., Stamm, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060464/
https://ncbi.nlm.nih.gov/pubmed/21220421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.183970
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