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Synthesis of a Norcantharidin-tethered Guanosine: Protein Phosphatase-1 Inhibitors That Change Alternative Splicing
Phosphorylation and dephosphorylation of splicing factors play a key role in pre-mRNA splicing events, and cantharidin and norcantharidin analogs inhibit protein phosphatase-1 (PP1) and change alternative pre-mRNA splicing. Targeted inhibitors capable of selectively inhibiting PP-1 could promote exo...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4728011/ https://ncbi.nlm.nih.gov/pubmed/26725024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.12.054 |
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