Mechanism of topology simplification by type II DNA topoisomerases

Type II DNA topoisomerases actively reduce the fractions of knotted and catenated circular DNA below thermodynamic equilibrium values. To explain this surprising finding, we designed a model in which topoisomerases introduce a sharp bend in DNA. Because the enzymes have a specific orientation relati...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Vologodskii, Alexander V., Zhang, Wentao, Rybenkov, Valentin V., Podtelezhnikov, Alexei A., Subramanian, Deepa, Griffith, Jack D., Cozzarelli, Nicholas R.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2001
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC30604/
https://ncbi.nlm.nih.gov/pubmed/11248029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061029098
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