Mechanism of topology simplification by type II DNA topoisomerases

Type II DNA topoisomerases actively reduce the fractions of knotted and catenated circular DNA below thermodynamic equilibrium values. To explain this surprising finding, we designed a model in which topoisomerases introduce a sharp bend in DNA. Because the enzymes have a specific orientation relati...

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Autors principals: Vologodskii, Alexander V., Zhang, Wentao, Rybenkov, Valentin V., Podtelezhnikov, Alexei A., Subramanian, Deepa, Griffith, Jack D., Cozzarelli, Nicholas R.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC30604/
https://ncbi.nlm.nih.gov/pubmed/11248029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061029098
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