Mechanism of topology simplification by type II DNA topoisomerases

Type II DNA topoisomerases actively reduce the fractions of knotted and catenated circular DNA below thermodynamic equilibrium values. To explain this surprising finding, we designed a model in which topoisomerases introduce a sharp bend in DNA. Because the enzymes have a specific orientation relati...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Vologodskii, Alexander V., Zhang, Wentao, Rybenkov, Valentin V., Podtelezhnikov, Alexei A., Subramanian, Deepa, Griffith, Jack D., Cozzarelli, Nicholas R.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 2001
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30604/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248029/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061029098
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