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Structural evolution of Iowa-mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth
Structural variations in β-amyloid fibrils are potentially important to the toxicity of these fibrils in Alzheimer's disease (AD). We describe a repeated seeding protocol that selects a homogeneous fibril structure from a polymorphic initial state in the case of 40-residue β-amyloid fibrils wit...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060308/ https://ncbi.nlm.nih.gov/pubmed/21355554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja109679q |
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