SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis

PURPOSE: Heparanase promotes myeloma growth, dissemination and angiogenesis through modulation of the tumor microenvironment, thus highlighting the potential of therapeutically targeting this enzyme. SST0001, a non-anticoagulant heparin with anti-heparanase activity was examined for its inhibition o...

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Autors principals: Ritchie, Joseph P., Ramani, Vishnu C., Ren, Yongsheng, Naggi, Annamaria, Torri, Giangiacomo, Casu, Benito, Penco, Sergio, Pisano, Claudio, Carminati, Paolo, Tortoreto, Monica, Zunino, Franco, Vlodavsky, Israel, Sanderson, Ralph D., Yang, Yang
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060291/
https://ncbi.nlm.nih.gov/pubmed/21257720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2476
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