SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis

PURPOSE: Heparanase promotes myeloma growth, dissemination and angiogenesis through modulation of the tumor microenvironment, thus highlighting the potential of therapeutically targeting this enzyme. SST0001, a non-anticoagulant heparin with anti-heparanase activity was examined for its inhibition o...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Ritchie, Joseph P., Ramani, Vishnu C., Ren, Yongsheng, Naggi, Annamaria, Torri, Giangiacomo, Casu, Benito, Penco, Sergio, Pisano, Claudio, Carminati, Paolo, Tortoreto, Monica, Zunino, Franco, Vlodavsky, Israel, Sanderson, Ralph D., Yang, Yang
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060291/
https://ncbi.nlm.nih.gov/pubmed/21257720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2476
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk