SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis

PURPOSE: Heparanase promotes myeloma growth, dissemination and angiogenesis through modulation of the tumor microenvironment, thus highlighting the potential of therapeutically targeting this enzyme. SST0001, a non-anticoagulant heparin with anti-heparanase activity was examined for its inhibition o...

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Bibliographic Details
Main Authors: Ritchie, Joseph P., Ramani, Vishnu C., Ren, Yongsheng, Naggi, Annamaria, Torri, Giangiacomo, Casu, Benito, Penco, Sergio, Pisano, Claudio, Carminati, Paolo, Tortoreto, Monica, Zunino, Franco, Vlodavsky, Israel, Sanderson, Ralph D., Yang, Yang
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060291/
https://ncbi.nlm.nih.gov/pubmed/21257720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2476
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