Učitavanje...
Theoretical study of the sequence specificity in the covalent binding of the antitumor drug CC-1065 to DNA.
A theoretical modelling is presented of the covalent adducts of the antitumor agent CC-1065 with B-DNA. The optimal complexes are obtained by energy minimisation, taking into account full structure flexibility, including the flexible rings of the ligand and DNA. The binding preference of CC-1065 wit...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
1987
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| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC306022/ https://ncbi.nlm.nih.gov/pubmed/3615201 |
| Oznake: |
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