Theoretical study of the sequence specificity in the covalent binding of the antitumor drug CC-1065 to DNA.
A theoretical modelling is presented of the covalent adducts of the antitumor agent CC-1065 with B-DNA. The optimal complexes are obtained by energy minimisation, taking into account full structure flexibility, including the flexible rings of the ligand and DNA. The binding preference of CC-1065 wit...
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| Yayımlandı: | Nucleic Acids Res |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
1987
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| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306022/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3615201/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/15.14.5775 |
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