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Theoretical study of the sequence specificity in the covalent binding of the antitumor drug CC-1065 to DNA.

A theoretical modelling is presented of the covalent adducts of the antitumor agent CC-1065 with B-DNA. The optimal complexes are obtained by energy minimisation, taking into account full structure flexibility, including the flexible rings of the ligand and DNA. The binding preference of CC-1065 wit...

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Bibliografiske detaljer
Main Authors: Zakrzewska, K, Randrianarivelo, M, Pullman, B
Format: Artigo
Sprog:Inglês
Udgivet: 1987
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC306022/
https://ncbi.nlm.nih.gov/pubmed/3615201
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