Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NFκB target genes

Metallothioneins (MTs) are potent scavengers of free radicals that are silenced in primary hepatocellular carcinomas (HCCs) of human and rodent origin. To examine whether loss of MT promotes hepatocarcinogenesis, male Mt-1 and Mt-2 double knockout (MTKO) and wild type (WT) mice were exposed to dieth...

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Bibliografische gegevens
Hoofdauteurs: Majumder, Sarmila, Roy, Satavisha, Kaffenberger, Thomas, Wang, Bo, Costinean, Stefan, Frankel, Wendy, Bratasz, Anna, Kuppusamy, Periannan, Hai, Tsonwin, Ghoshal, Kalpana, Jacob, Samson T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059562/
https://ncbi.nlm.nih.gov/pubmed/21159647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2839
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