Hepatic Loss of miR-122 Predisposes Mice to Hepatobiliary Cyst and Hepatocellular Carcinoma upon Diethylnitrosamine Exposure

Loss of miR-122 causes chronic steatohepatitis and spontaneous hepatocellular carcinoma. However, the consequence of miR-122 deficiency on genotoxic stress–induced liver pathogenesis is poorly understood. Here, we investigated the impact of miR-122 depletion on liver pathobiology by treating liver-s...

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Detalhes bibliográficos
Main Authors: Hsu, Shu-hao, Wang, Bo, Kutay, Huban, Bid, Hemant, Shreve, Julia, Zhang, Xiaoli, Costinean, Stefan, Bratasz, Anna, Houghton, Peter, Ghoshal, Kalpana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857547/
https://ncbi.nlm.nih.gov/pubmed/24113455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.08.004
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