A role for IL-27p28 as an antagonist of gp130-mediated signaling

The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit combined with gp130, a common receptor chain utilized by several cytokines, including IL-6. Interestingly, the IL-27 subunits p28 and EBI3 are not always co-expressed, suggesting that they may have unique functions...

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Detalhes bibliográficos
Main Authors: Stumhofer, Jason S., Tait, Elia D., Quinn, William J., Hosken, Nancy, Spudy, Björn, Goenka, Radhika, Fielding, Ceri A., O’Hara, Aisling C., Chen, Yi, Jones, Michael L., Saris, Christiaan J. M., Rose-John, Stefan, Cua, Daniel J., Jones, Simon A., Elloso, Merle M., Grötzinger, Joachim, Cancro, Michael P., Levin, Steven D., Hunter, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059498/
https://ncbi.nlm.nih.gov/pubmed/21057510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1957
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