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Mapping the early steps in the pH-induced conformational conversion of the prion protein
Under certain conditions, the prion protein (PrP) undergoes a conformational change from the normal cellular isoform, PrP(C), to PrP(Sc), an infectious isoform capable of causing neurodegenerative diseases in many mammals. Conversion can be triggered by low pH, and in vivo this appears to take place...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC30593/ https://ncbi.nlm.nih.gov/pubmed/11248018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061555898 |
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