Aim2-deficiency stimulates the expression of interferon-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus

Murine Aim2 and p202 proteins (encoded by the Aim2 and Ifi202 genes) are members of the interferon (IFN)-inducible p200-protein family. Both proteins can sense double-stranded DNA (dsDNA) in the cytoplasm. However, upon sensing dsDNA, only the Aim2 protein through its pyrin domain (PYD) can form an...

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Autori principali: Panchanathan, Ravichandran, Duan, Xin, Shen, Hui, Rathinam, Vijay A. K., Erickson, Loren D., Fitzgerald, Katherine A, Choubey, Divaker
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059233/
https://ncbi.nlm.nih.gov/pubmed/21057088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002468
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