Arginine Deficiency Causes Runting in the Suckling Period by Selectively Activating the Stress Kinase GCN2

Suckling “F/A2” mice, which overexpress arginase-I in their enterocytes, develop a syndrome (hypoargininemia, reduced hair and muscle growth, impaired B-cell maturation) that resembles IGF1 deficiency. The syndrome may result from an impaired function of the GH-IGF1 axis, activation of the stress-ki...

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Bibliografiska uppgifter
Huvudupphovsmän: Marion, Vincent, Sankaranarayanan, Selvakumari, de Theije, Chiel, van Dijk, Paul, Lindsey, Patrick, Lamers, Marinus C., Harding, Heather P., Ron, David, Lamers, Wouter H., Köhler, S. Eleonore
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058991/
https://ncbi.nlm.nih.gov/pubmed/21239484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.216119
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