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Quantitative reactivity profiling predicts functional cysteines in proteomes

Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is tuned to perform diverse biochemical functions. The absence of a consensus sequence that defines functional cysteines in proteins has hindered their discovery and characterization. Here, we describe a pro...

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Bibliografische gegevens
Hoofdauteurs: Weerapana, Eranthie, Wang, Chu, Simon, Gabriel M., Richter, Florian, Khare, Sagar, Dillon, Myles B.D., Bachovchin, Daniel A., Mowen, Kerri, Baker, David, Cravatt, Benjamin F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058684/
https://ncbi.nlm.nih.gov/pubmed/21085121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09472
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