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A quantitative chemoproteomic platform to monitor selenocysteine reactivity within a complex proteome

Mammalian selenocysteine (Sec) containing proteins, selenoproteins, are important to (patho)physiological processes, including redox homeostasis. Sec residues have been recalcitrant to mass spectrometry (MS)-based chemoproteomic methods that enrich for reactive cysteine (Cys) residues with electroph...

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Bibliographic Details
Published in:Cell Chem Biol
Main Authors: Bak, Daniel W., Gao, Jinjun, Wang, Chu, Weerapana, Eranthie
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510024/
https://ncbi.nlm.nih.gov/pubmed/29983274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.05.017
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