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Reactive-cysteine profiling for drug discovery
The recognition that only a small percentage of known human gene products are druggable using traditional modes of non-covalent ligand design, has led to a resurgence in targeted covalent inhibitors. Covalent inhibitors offer advantages over non-covalent inhibitors in engaging otherwise challenging...
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| Publicado no: | Curr Opin Chem Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6584045/ https://ncbi.nlm.nih.gov/pubmed/30897495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2019.02.010 |
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