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An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells
The IL-2/IL-2R signaling pathway plays an important role in autoimmunity. Several genes identified in GWA studies encode proteins in the IL-2/IL-2R signaling cascade that are associated with autoimmune diseases. One of these, PTPN2, encodes a protein tyrosine phosphatase that is highly expressed in...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3058680/ https://ncbi.nlm.nih.gov/pubmed/21179116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2010.54 |
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