The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance of adult mouse hematopoietic stem cells (HSCs) remains unknown. Although normal HSCs sustain life-long hematopoiesis, malignant transformation of HSCs leads to leukemia. Therefore, mechanisms pr...

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Bibliografische gegevens
Hoofdauteurs: Mortensen, Monika, Soilleux, Elizabeth J., Djordjevic, Gordana, Tripp, Rebecca, Lutteropp, Michael, Sadighi-Akha, Elham, Stranks, Amanda J., Glanville, Julie, Knight, Samantha, W. Jacobsen, Sten-Eirik, Kranc, Kamil R., Simon, Anna Katharina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058574/
https://ncbi.nlm.nih.gov/pubmed/21339326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20101145
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