Mos activates MAP kinase in mouse oocytes through two opposite pathways

Activation of mitogen-activated protein kinase (MAPK) in maturing mouse oocytes occurs after synthesis of Mos, a MAPKKK. To investigate whether Mos acts only through MEK1, we microinjected constitutively active forms of MEK1 (MEK1S218D/S222D referred herein as MEK*) and Raf (ΔRaf) into mouse oocytes...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Verlhac, Marie-Hélène, Lefebvre, Christophe, Kubiak, Jacek Z., Umbhauer, Muriel, Rassinier, Pascale, Colledge, William, Maro, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
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Articles
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305841/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11080153/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.22.6065
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