A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination

RNA crystallization and phasing represent major bottlenecks in RNA structure determination. Seeking to exploit antibody fragments as RNA crystallization chaperones, we have used an arginine-enriched synthetic Fab library displayed on phage to obtain Fabs against the class I ligase ribozyme. We solve...

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Main Authors: Koldobskaya, Yelena, Duguid, Erica M., Shechner, David M., Suslov, Nikolai B., Ye, Jingdong, Sidhu, Sachdev S., Bartel, David P., Koide, Shohei, Kossiakoff, Anthony A., Piccirilli, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058332/
https://ncbi.nlm.nih.gov/pubmed/21151117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1945
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